The three distinct sub-types of depression were characterized by two main factors: functional connectivity patterns synchronized between different regions of the brain and childhood trauma experience. They found that the brain's functional connectivity in regions that involved the angular gyrus—a brain region associated with processing language and numbers, spatial cognition, attention, and other aspects of cognition—played a large role in determining whether SSRIs were effective in treating depression.
Patients with increased functional connectivity between the brain's different regions who had also experienced childhood trauma had a sub-type of depression that is unresponsive to treatment by SSRIs drugs, the researchers found. On the other hand, the other two subtypes – where the participants' brains did not show increased connectivity among its different regions or where participants had not experienced childhood trauma – tended to respond positively to treatments using SSRIs drugs.
This study not only identifies sub-types of depression for the first time, but also identifies some underlying factors and points to the need to explore new treatment techniques. "It provides scientists studying neurobiological aspects of depression a promising direction in which to pursue their research," says Prof. Doya. In time, he and his research team hope that these results will help psychiatrists and therapists improve diagnoses and treat their patients more effectively.
ako sam dobro shvatio clanak nasli su razlog zasto neki depresivci ne reaguju na ssri pa sam mislio da je vredno da podellim sa vama
oni depresivci koji su iskusili traumu u detinjstvu a istovremeno imaju jaku "funkcionalnu ispovezivanost" odredjenih delova mozga NECE dobro reagovati na ssri
s druge strane oni koji imaju slabu ispovezivanost ILI imaju jaku ali nisu iskusili traumu ce reagovati dobro