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posledice nefunkcionalnog nmda receptora mogu biti izlečene


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#1 ĐeneĐene

ĐeneĐene

    correct me!

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Posted 14 December 2017 - 19:59

izvinite na šlj prevodu abstrakta ovog naučnog članka
https://www.biorxiv....17/05/20/140343

Quote

NMDA receptors (NMDAR) are important in the formation of activity-dependent connections in the brain. In sensory pathways, NMDAR disruption during discrete developmental periods has enduring effects on wiring and function. Yet, it is not clear whether NMDAR-limited critical periods exist for higher-order circuits governing mood and cognition. This question is urgent for neurodevelopmental disorders, like schizophrenia, that have NMDAR hypofunction and treatment-resistant cognitive symptoms. As proof of concept, we developed a novel mouse model where developmental NMDAR deficits can be ameliorated by inducible Cre recombinase. Rescue of NMDARs in either adolescence or adulthood yields surprisingly strong improvements in higher-order behavior. Similar levels of behavioral plasticity are observed regardless of intervention age, with degree of plasticity dependent on the specific behavioral circuit. These results reveal higher-order brain function as amenable to treatment in adulthood and identify NMDAR as a key target for cognitive dysfunction.

nisu pronašli lek ali su potvrdili pre svega značaj nmda receptora za šizofreniju
plus su pokazali da će neki budući lek ili genetska terapija povratiti mozak u normalno stanje čak i u odraslom dobu

do tada ostaje da se koriste suplementi koji veštački potenciraju nmda receptor
a to su sarkozin i natrijum benzoat da ja znam

#2 Iimitless

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Posted 14 December 2017 - 20:15

Natrijum benzoat je konzervans :D

#3 ĐeneĐene

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Posted 14 December 2017 - 20:21

znam to ali se testira i pod nazivom NaBen kao dodatak terapiji šizofrenije
pokazao je poboljšanje od 21% na panss skali što nije baš wooow ali možda nekome bude značilo makar kakvo poboljšanje


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